--- title: Why you need to calibrate pressure sensors in a cleanroom description: There are many applications for differential pressure transducers, but none are more critical than those measuring the pressure parameters in a cleanroom. image: https://www.setra.com/hubfs/Blog_Pictures/2017-08-10%20Pressure%20Calibration%20for%20Cleanrooms%20NO%20OVERLAY.png --- ** ** ** - Website Pages - Products [![Setra Systems Logo](https://www.setra.com/hubfs/setra-logo.svg "Setra Systems Logo")](https://www.setra.com/) ![drop-down-pressure](https://www.setra.com/hs-fs/hubfs/angle-arrow-pointing-to-right.png?width=15&name=angle-arrow-pointing-to-right.png) **[Pressure Sensors](https://www.setra.com/product/pressure)** [Differential Pressure Sensors](https://www.setra.com/product/pressure/differential) [Absolute Pressure Sensors](https://www.setra.com/product/pressure/absolute) [Barometric Pressure Sensors](https://www.setra.com/product/pressure/barometric) [Compound Pressure Sensors](https://www.setra.com/product/pressure/compound) [Gauge Pressure Sensors](https://www.setra.com/product/pressure/gauge) [Submersible Pressure Sensors](https://www.setra.com/product/pressure/submersible) [Vacuum Pressure Sensors](https://www.setra.com/product/pressure/vacuum) [UHP Pressure Sensors](https://www.setra.com/product/pressure/uhp) **[Room Pressure Monitors](https://www.setra.com/product/room-pressure-monitors)** **[Pressure Calibrator](https://www.setra.com/product/calibration/microcal-pressure-calibrator)** **[Setra CEMS™ Software](https://www.setra.com/cems)** **[Power Meters & Accessories](https://www.setra.com/product/power-meters)** **[Particle Counters](https://www.setra.com/product/particle-counters)** **[Wireless Solution Systems](https://www.setra.com/wireless)** **[Humidity/Temp Sensors](https://www.setra.com/product/humidity)** **[Dolan-Jenner Fiber Optics](https://dolan-jenner.com)** ![drop-down-pressure](https://www.setra.com/hs-fs/hubfs/angle-arrow-pointing-to-right.png?width=15&name=angle-arrow-pointing-to-right.png) **[Building Automation](https://www.setra.com/building-automation)** [Calibration](https://www.setra.com/building-automation/calibration-equipment) [HVAC/R OEM](https://www.setra.com/building-automation/hvac-r-oem-applications) [HVAC/R](https://www.setra.com/building-automation/hvac-applications) **[Cleanrooms](https://www.setra.com/critical-environments)** **[Healthcare](https://www.setra.com/critical-environments/healthcare)** ![drop-down-pressure](https://www.setra.com/hs-fs/hubfs/angle-arrow-pointing-to-right.png?width=15&name=angle-arrow-pointing-to-right.png) **[General Industrial](https://www.setra.com/industrial)** [Alternative Fuels](https://www.setra.com/general-industrial/vacuum-pressure-in-alternative-fuels) [Barometric](https://www.setra.com/general-industrial/barometric-pressure-measurement-tools) [Data Centers](https://www.setra.com/applications/data-centers/pressure-sensors) [General Industrial OEM](https://www.setra.com/quality-approved-general-industrial-oem-solutions-setra-systems) [HVAC/R OEM](https://www.setra.com/building-automation/hvac-r-oem-applications) [Medical](https://www.setra.com/applications/medical-devices/pressure-sensors) [Off-Highway Vehicles](https://www.setra.com/general-industrial/pressure-transducers-for-off-highway-vehicles) [Oil & Gas](https://www.setra.com/general-industrial/oil-and-gas-pressure-measurement) [Process / MFG Tank Level](https://www.setra.com/general-industrial/liquid-level-sensors) [Test & Measurement](https://www.setra.com/general-industrial/pressure-test-and-measurement) [Water & Wastewater](https://www.setra.com/general-industrial/liquid-level-sensors-for-water-processing) **[Semiconductor Manufacturing](https://www.setra.com/semiconductor-manufacturing-pressure-measurement)** **[Data Centers](https://www.setra.com/applications/data-centers)** **[Energy Management](https://www.setra.com/energy-management)** **[Fiber Optics](https://www.setra.com/fiber-optic-illuminators)** **[Scales](https://www.setra.com/counting-scales-and-laboratory-balances)** [![setra-nav-logo.png](https://www.setra.com/hs-fs/hubfs/setra-nav-logo.png?width=133&name=setra-nav-logo.png "setra-nav-logo.png")](https://www.setra.com/) ![Menu](https://www.setra.com/hs-fs/hubfs/moble-icon.jpg?width=30&name=moble-icon.jpg) × [Home](https://www.setra.com) Markets > [Healthcare](https://www.setra.com/critical-environments/healthcare) [Building Automation](https://www.setra.com/building-automation) [Cleanrooms](https://www.setra.com/critical-environments) [General Industrial](https://www.setra.com/industrial) [Semiconductor Manufacturing](https://www.setra.com/semiconductor-manufacturing-pressure-measurement) [Data Centers](https://www.setra.com/applications/data-centers?hsLang=en) [Energy Management](https://www.setra.com/energy-management) [Fiber Optics](https://www.setra.com/fiber-optic-illuminators) [Scales](https://www.setra.com/counting-scales-and-laboratory-balances) Products > [Pressure Sensors](https://www.setra.com/product/pressure) [Room Pressure Monitors](https://www.setra.com/product/room-pressure-monitors) [Particle Counters](https://www.setra.com/product/particle-counters) [Setra CEMS™ Software](https://www.setra.com/cems) [Power Meter & Accessories](https://www.setra.com/product/power-meters) [Pressure Calibrator](https://www.setra.com/product/calibration/microcal-pressure-calibrator) [Wireless Solutions Systems](https://www.setra.com/wireless) [Humidity/Temp Sensors](https://www.setra.com/product/humidity) [Dolan-Jener](https://dolan-jenner.com/) [OEM Solutions](https://www.setra.com/custom-solutions) Resources > [Blog](https://www.setra.com/blog) [Videos](https://www.setra.com/video-resources) [FAQs](https://article.setra.com/) [Compliance](https://article.setra.com/compliance-documents) [Supplier](https://www.setra.com/support/supplier) [Current Customers](https://www.setra.com/support/customer) [Order Online](https://ecatalog.setra.com) Returns > [Services & Calibration](https://www.setra.com/support/service) [New and Unused for Credit](https://www.setra.com/product-return) [Contact Us](https://www.setra.com/help-center) # Why you need to calibrate pressure sensors in a cleanroom #### by [Tom Lish](https://www.setra.com/blog/author/tom-lish) - [Tweet](https://twitter.com/share) ![Why you need to calibrate pressure sensors in a cleanroom](https://www.setra.com/hs-fs/hubfs/Blog_Pictures/2017-08-10%20Pressure%20Calibration%20for%20Cleanrooms%20NO%20OVERLAY.png?width=1024&name=2017-08-10%20Pressure%20Calibration%20for%20Cleanrooms%20NO%20OVERLAY.png "Why you need to calibrate pressure sensors in a cleanroom") There are many applications for differential pressure transducers, but none are more critical than those measuring the pressure parameters in a [cleanroom](https://www.setra.com/cleanroom-monitoring). A cleanroom is a critical area used to manufacture medications, containers, enclosures, and other medical devices that require the [products to remain sterile](https://www.setra.com/blog/5-common-sources-of-contamination-in-a-cleanroom?_ga=2.235888257.187666151.1558008162-1074101361.1552314123) from manufacturing through delivery to the customer. The products manufactured in these environments are used to treat and care for the general population and are handled differently than other products. ## Regulatory Guidelines The FDA has stringent guidelines for sterile drug products that are produced by aseptic processing requiring them to meet cGMP practices throughout processing. Cleanrooms carry various classifications depending on the product that’s being manufactured within that space. A cleanroom is a positively pressurized space designed to ensure that the particulates within the room meet requirements based on the classification of the room. ![ISO 14644-1 Cleanroom Standards](https://www.setra.com/hs-fs/hubfs/2017-08-10%20ISO%20Cleanroom%20Standards.jpg?width=680&name=2017-08-10%20ISO%20Cleanroom%20Standards.jpg "ISO 14644-1 Cleanroom Standards")             **ISO 14644-1:** Covers the classification of air cleanliness in cleanrooms and associated controlled environments exclusively in terms of concentration of airborne particles. **ISO 14644-2:** Specifies requirements for periodic testing of a cleanroom or clean zone to prove its continued compliance with ISO 14644-1 for the designated classification of airborne particulate cleanliness. **SETRA BLOG: [How can employees contaminate a cleanroom?](https://www.setra.com/blog/how-can-personnel-contaminate-a-clean-environment)** ## Cleanroom Design Many design parameters need to be considered when designing a new cleanroom; airflow, air changes per hour, the product manufactured in the space and many more. One of the more critical considerations on room operation is the calibration of the differential pressure transducers used in conjunction with the [HVAC system](https://www.setra.com/building-automation/hvac-r-oem-applications?_ga=2.235888257.187666151.1558008162-1074101361.1552314123) to control these environments. [Differential pressure transducers](https://www.setra.com/products?_ga=2.235888257.187666151.1558008162-1074101361.1552314123#pressure.differential) play a pivotal role in the integrity of the cleanroom. These sensors perform measurements of HEPA filter cleanliness, airflow, and proper static pressure between the cleanroom and the adjacent space. Within the clean room space the pressure measurements taken are extremely low, often controlled to below 0.1”WC. Cleanrooms are primarily designed to maintain a sterile environment, but also have a focus on energy efficiency. [The HVAC control system uses the feedback from differential pressure transducers](https://www.setra.com/blog/what-is-a-pid-loop?_ga=2.235888257.187666151.1558008162-1074101361.1552314123) to maintain control of the clean room at very low pressure levels, allowing fans to run less and save the conditioned air within the room. A critical component to maintaining accurate positive pressure within a cleanroom is the proper calibration of the differential pressure transducers used in the HVAC system of the space. ## Sensor Calibration Pharmaceutical manufacturers have millions of dollars invested in research and finished product within a cleanroom. In order to protect this investment, the manufactures follow documented standard operating procedures to validate and, if needed, calibrate the differential pressure sensors used to comply with FDA guidelines. Portable [pressure calibrators](https://www.setra.com/products/calibration/microcal-advanced-modular-pressure-calibrator?_ga=2.235888257.187666151.1558008162-1074101361.1552314123) are the preferred device of pharmaceutical manufacturers; these facilities have hundreds of sensors throughout their building. The choice of a pressure calibrator can be a difficult choice to make. The 2 critical considerations are the reference standard as well as the pressure generation system of the calibrator. Most manufactures of low pressure calibrators do not use properly ranged pressure references. Instead, these high range sensors attempt to achieve high accuracy at low pressures through intricate microprocessor correction resulting in higher levels of noise and instability limiting the ultimate accuracy available. **Did you know? More and more hospital pharmacies are moving towards cleanroom standards? [CLICK HERE to learn more.](https://www.setra.com/blog/hospital-pharmacies-moving-toward-clean-room-standards)** **[![Pressure Calibration Brochure](https://no-cache.hubspot.com/cta/default/211498/b60037c1-644c-4283-abde-28247fd60ee7.png)](https://cta-redirect.hubspot.com/cta/redirect/211498/b60037c1-644c-4283-abde-28247fd60ee7)**   Topics: [Critical Environments](https://www.setra.com/blog/topic/critical-environments), [Building Automation](https://www.setra.com/blog/topic/building-automation), [Calibration](https://www.setra.com/blog/topic/calibration), [HVAC/R](https://www.setra.com/blog/topic/hvac-r) ### Recent Posts ### Posts by Topic - [Critical Environments (184)](https://www.setra.com/blog/topic/critical-environments) - [HVAC/R (180)](https://www.setra.com/blog/topic/hvac-r) - [General Industrial (153)](https://www.setra.com/blog/topic/general-industrial) - [Building Automation (135)](https://www.setra.com/blog/topic/building-automation) - [General Industrial OEM (92)](https://www.setra.com/blog/topic/general-industrial-oem) - [Energy Management (85)](https://www.setra.com/blog/topic/energy-management) - [Test and Measurement (66)](https://www.setra.com/blog/topic/test-and-measurement) - [HVAC/R OEM (60)](https://www.setra.com/blog/topic/hvac-r-oem) - [Barometric (44)](https://www.setra.com/blog/topic/barometric) - [Alternative Fuels (42)](https://www.setra.com/blog/topic/alternative-fuels) - [Medical (41)](https://www.setra.com/blog/topic/medical) - [Process/Mfg Tank Level (40)](https://www.setra.com/blog/topic/process-mfg-tank-level) - [Water and Wastewater (39)](https://www.setra.com/blog/topic/water-and-wastewater) - [OHV (38)](https://www.setra.com/blog/topic/ohv) - [Oil and Gas (35)](https://www.setra.com/blog/topic/oil-and-gas) - [Industrial Vacuum (29)](https://www.setra.com/blog/topic/industrial-vacuum) - [Calibration (25)](https://www.setra.com/blog/topic/calibration) - [Semiconductor (25)](https://www.setra.com/blog/topic/semiconductor) - [Particle Counting (20)](https://www.setra.com/blog/topic/particle-counting) - [Cleanroom Monitoring (18)](https://www.setra.com/blog/topic/cleanroom-monitoring) - [Room Pressure Monitoring (17)](https://www.setra.com/blog/topic/room-pressure-monitoring) - [Trade Show (12)](https://www.setra.com/blog/topic/trade-show) - [cleanroom environment (12)](https://www.setra.com/blog/topic/cleanroom-environment) - [Environmental Monitoring (11)](https://www.setra.com/blog/topic/environmental-monitoring) - [Power Meters (11)](https://www.setra.com/blog/topic/power-meters) - [Scales (11)](https://www.setra.com/blog/topic/scales) - [Healthcare (10)](https://www.setra.com/blog/topic/healthcare) - [Power Monitoring (10)](https://www.setra.com/blog/topic/power-monitoring) - [Software (9)](https://www.setra.com/blog/topic/software) - [cleanroom monitoring systems (9)](https://www.setra.com/blog/topic/cleanroom-monitoring-systems) - [Case Study (8)](https://www.setra.com/blog/topic/case-study) - [critical environment technologies (8)](https://www.setra.com/blog/topic/critical-environment-technologies) - [data centers (8)](https://www.setra.com/blog/topic/data-centers) - [Humidity (7)](https://www.setra.com/blog/topic/humidity) - [particle counter (6)](https://www.setra.com/blog/topic/particle-counter) - [pressure transducers (6)](https://www.setra.com/blog/topic/pressure-transducers) - [LITE room pressure monitor (5)](https://www.setra.com/blog/topic/lite-room-pressure-monitor) - [hardware and software cleanroom monitoring systems (5)](https://www.setra.com/blog/topic/hardware-and-software-cleanroom-monitoring-systems) - [setra lite (5)](https://www.setra.com/blog/topic/setra-lite) - [Compliance (4)](https://www.setra.com/blog/topic/compliance) - [Video (3)](https://www.setra.com/blog/topic/video) - [hospital spaces (3)](https://www.setra.com/blog/topic/hospital-spaces) - [FAQ & Troubleshooting (2)](https://www.setra.com/blog/topic/faq-troubleshooting) - [Monitoring Compounding Pharmacies (2)](https://www.setra.com/blog/topic/monitoring-compounding-pharmacies) - [Semiconductor Manufacturing (2)](https://www.setra.com/blog/topic/semiconductor-manufacturing) - [agencies that monitor pharmacies (2)](https://www.setra.com/blog/topic/agencies-that-monitor-pharmacies) - [energy (2)](https://www.setra.com/blog/topic/energy) - [hvac (2)](https://www.setra.com/blog/topic/hvac) - [laboratories (2)](https://www.setra.com/blog/topic/laboratories) - [monitor compound pharmacy (2)](https://www.setra.com/blog/topic/monitor-compound-pharmacy) - [protected environment (2)](https://www.setra.com/blog/topic/protected-environment) - [regulatory compliance (2)](https://www.setra.com/blog/topic/regulatory-compliance) - [setra lite features (2)](https://www.setra.com/blog/topic/setra-lite-features) - [usp 797 (2)](https://www.setra.com/blog/topic/usp-797) - [Application Note (1)](https://www.setra.com/blog/topic/application-note) - [Current Sensors and Transducers (1)](https://www.setra.com/blog/topic/current-sensors-and-transducers) - [Current Transformers (1)](https://www.setra.com/blog/topic/current-transformers) - [Lithium-Ion Battery (1)](https://www.setra.com/blog/topic/lithium-ion-battery) - [Pressure (1)](https://www.setra.com/blog/topic/pressure) - [aerospace cleanrooms (1)](https://www.setra.com/blog/topic/aerospace-cleanrooms) - [cems (1)](https://www.setra.com/blog/topic/cems) - [digital transformation (1)](https://www.setra.com/blog/topic/digital-transformation) - [ipv6 multicast (1)](https://www.setra.com/blog/topic/ipv6-multicast) - [ipv6 multicast address (1)](https://www.setra.com/blog/topic/ipv6-multicast-address) - [ipv6 multicast address range (1)](https://www.setra.com/blog/topic/ipv6-multicast-address-range) - [isolation room pressure monitoring (1)](https://www.setra.com/blog/topic/isolation-room-pressure-monitoring) - [multicast address ipv6 (1)](https://www.setra.com/blog/topic/multicast-address-ipv6) - [multicast ipv6 (1)](https://www.setra.com/blog/topic/multicast-ipv6) - [operating room (1)](https://www.setra.com/blog/topic/operating-room) - [pharma 4.0 (1)](https://www.setra.com/blog/topic/pharma-4-0) - [pressure sensor (1)](https://www.setra.com/blog/topic/pressure-sensor) - [pressure transducer companies (1)](https://www.setra.com/blog/topic/pressure-transducer-companies) - [semi conductor (1)](https://www.setra.com/blog/topic/semi-conductor) - [sensors and transducers (1)](https://www.setra.com/blog/topic/sensors-and-transducers) - [setra pressure transducers (1)](https://www.setra.com/blog/topic/setra-pressure-transducers) - [submetering (1)](https://www.setra.com/blog/topic/submetering) - [sustainability (1)](https://www.setra.com/blog/topic/sustainability) - [temperature monitor (1)](https://www.setra.com/blog/topic/temperature-monitor) - [temperature monitoring for pharmacies (1)](https://www.setra.com/blog/topic/temperature-monitoring-for-pharmacies) - [transducers (1)](https://www.setra.com/blog/topic/transducers) - [usp 800 (1)](https://www.setra.com/blog/topic/usp-800) - [water (1)](https://www.setra.com/blog/topic/water) - [what does hvac stand for (1)](https://www.setra.com/blog/topic/what-does-hvac-stand-for) - [what is a transducer (1)](https://www.setra.com/blog/topic/what-is-a-transducer) - [what is hvac (1)](https://www.setra.com/blog/topic/what-is-hvac) [see all](https://www.setra.com/blog/sensor-calibration-for-cleanroons#) [![HVAC Catalog Cover Image 1](https://www.setra.com/hs-fs/hubfs/HVAC%20Catalog%20Cover%20Image%201.png?width=160&name=HVAC%20Catalog%20Cover%20Image%201.png "HVAC Catalog Cover Image 1")](http://setrasystems.uberflip.com/setra-systems/hvac-catalog-feb-2017)   **HVAC Catalog**   This comprehensive HVAC Product Catalog is now available online. [Download the PDF now.](http://setrasystems.uberflip.com/setra-systems/hvac-catalog-feb-2017)   - [**](https://www.facebook.com/SetraSystems) - [**](https://twitter.com/setrasystems) - [**](https://www.youtube.com/user/SetraSystems) - [**](https://www.linkedin.com/company/setra-systems) - [**](https://www.instagram.com/setrasystemsinc/) [Service & Calibration](https://www.setra.com/support/service) | [Products](https://www.setra.com/products) | [Service/RMA](https://www.setra.com/support/service) | [Supplier](https://www.setra.com/support/supplier) | [Customer](https://www.setra.com/support/customer) | [Contact Us](https://www.setra.com/contact-us) | [FAQs](https://faq.setra.com) | [About](https://www.setra.com/about) | [Careers](https://careers.fortive.com/gems-setra/) | [Request Quote](https://www.setra.com/request-a-quote) | [Blog](https://www.setra.com/blog) Cookie Settings 159 Swanson Road Boxborough, MA 01719 | [orders@setra.com](mailto:orders@setra.com) [+1 (978) 263-1400 ](tel:+19782631400) Copyright © 2026 Setra Systems. All Rights Reserved. | [Terms & Conditions](https://www.setra.com/terms-and-conditions) | [Privacy Notice](https://www.setra.com/privacy-policy) | [ISO 9001:2015 Certified | ](https://www.setra.com/hubfs/ISO%20Setra%20LLC%202025.pdf)[Prop 65](https://www.setra.com/prop65) | [Patents](https://www.setra.com/patents) | [Cookies](https://www.setra.com/cookies) [![Setra Systems Logo](https://www.setra.com/hs-fs/hubfs/setra-systems-logo_white-1.png?width=100&name=setra-systems-logo_white-1.png)](https://www.setra.com/)[![Ralliant logo](https://www.setra.com/hs-fs/hubfs/Ralliant_Logo_SingleColor_White_RGB.png?width=125&name=Ralliant_Logo_SingleColor_White_RGB.png "Setra Systems is a Ralliant Company")](https://www.ralliant.com/)